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99mTc-MDP SPECT/CT Demonstrating Extraosseous Periarticular Amyloid Deposits in Primary Systemic Amyloidosis Associated With Multiple Myeloma

Agarwal, Krishan Kant, MD; Karunanithi, Sellam, MD; Roy, Shambo Guha, MBBS; Bal, Chandrasekhar, MD, DSc (HC); Kumar, Rakesh, MD, PhD

doi: 10.1097/RLU.0000000000000593
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Amyloidosis is a rare disorder characterized by variable extracellular accumulation of a complex substance consisting of proteinaceous fibrils (amyloid fibrils) and nonfibrillar glycoprotein or amyloid P component. We present a case of a primary systemic amyloidosis associated with multiple myeloma in a 48-year-old woman whose 99mTc-MDP SPECT/CT study revealed extraosseous periarticular uptake in amyloid deposits with no abnormal focal tracer uptake in the bone.

From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Received for publication October 26, 2013; revision accepted March 10, 2014.

Conflicts of interest and sources of funding: none declared.

Reprints: Rakesh Kumar, MD, PhD, E-81, Ansari Nagar (East), All India Institute of Medical Sciences Campus, New Delhi-110029, India. E-mail:

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