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131I Uptake in Intraosseous Hemangioma of the Skull

Mimicking a Bone Metastasis in Thyroid Cancer

Lee, Minkyung, MD*; Lee, Yu Kyung, MD*; Jeon, Tae Joo, MD, PhD*; Park, Cheong Soo, MD, PhD; Ryu, Young Hoon, MD, PhD*

doi: 10.1097/RLU.0000000000000467
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We report a case of unusual 131I uptake in the skull in a patient who received total thyroidectomy and cervical lymph node dissection for papillary thyroid carcinoma. This uptake mimicked a bone metastasis on posttherapeutic 131I whole-body scan. The lesion was further evaluated by 131I SPECT/CT and MRI, and it was identified as intraosseous hemangioma. For the prevention of unnecessary repeat ablation therapies and physicians’ confusion, the nuclear medicine physicians have to consider the 131I accumulation in the skull intraosseous hemangioma as a possible cause of false-positive uptake.

From the *Department of Nuclear Medicine, Gangnam Severance Hospital, and †Thyroid Cancer Center, Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea.

Received for publication November 26, 2013; revision accepted March 17, 2014.

Conflicts of interest and sources of funding: none declared.

Reprints: Young Hoon Ryu, MD, PhD, Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 712, Eonjuro, Gangnam-Gu, Seoul 135-720, South Korea. E-mail:

© 2014 by Lippincott Williams & Wilkins