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Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

Vercellino, Laetitia MD*†; Ohnona, Jessica MD*†; Groheux, David MD, PhD*†; Slama, Abdelhak MD*†; Colletti, Patrick M. MD; Chondrogiannis, Sotirios MD§; Merlet, Pascal MD*†; Toubert, Marie-Elisabeth MD*†; Rubello, Domenico MD§

doi: 10.1097/RLU.0b013e31829af8c0
Review Article

Aim The purpose of this study was to conduct a systematic review of the published literature to assess the role (indications, advantages, and limitations) of SPECT/CT for the detection of sentinel lymph node (SLN) in breast cancer.

Methods The authors searched PubMed for published literature in English addressing this topic.

Results Eleven studies, published since 2006, focused on the role and value of SPECT/CT for SLN detection (SLND). They showed that SPECT/CT improved sentinel node detection and anatomical localization. One study suggested that SPECT/CT may provide a more accurate staging. Limitations for SLND with SPECT/CT include extra time and inconvenience for the patient and additional radiation dose.

Conclusions SPECT/CT is a valuable tool for SLND, especially in difficult cases, when planar lymphoscintigraphy shows no SLN or unexpected lymphatic drainage.

From the *Nuclear Medicine Department, Saint Louis Hospital, APHP, Paris, and †UCK, U728 INSERM, IUH, Paris, France; ‡Department of Radiology, University of Southern California, Los Angeles, CA; and §Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy.

Received for publication March 21, 2013; and revision accepted April 24, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Domenico Rubello, MD, Department of Imaging, Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Via Tre Martiri 140, 45100 Rovigo, Italy. E-mail: domenico.rubello@libero.it.

© 2014 by Lippincott Williams & Wilkins