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Potential Role of FDG PET/CT in Evaluating Patients With Hepatic Incidentalomas

Grassetto, Gaia MD*; Marzola, Maria Cristina MD*; Chondrogiannis, Sotirios MD*; Maffione, Anna Margherita MD*; Rampin, Lucia MD*; Galeotti, Fabrizio MD; Colletti, Patrick M. MD; Rubello, Domenico MD*

doi: 10.1097/RLU.0000000000000312
Review Article

This review article is focused on the role of FDG PET/CT in diagnosing and characterizing hepatic incidentalomas. A large variety of unsuspected lesions can be detected in the liver both with ultrasound and CT performed for other reasons; the prevalence of liver incidentalomas increases in patients with chronic liver disease or preexisting oncologic history. The major challenge is to discriminate benign from malignant lesions. There is a large body of literature indicating that FDG PET/CT is a useful tool to this purpose even if it is unspecific (ie, it cannot differentiate a primary tumor from a secondary lesion). Occasionally, FDG PET/CT can be useful for biopsy guidance.

From the Departments of *Nuclear Medicine, and †Surgery, Santa Maria della Misericordia Hospital, Rovigo, Italy; and ‡Department of Radiology, University of Southern California, Los Angeles, CA.

Received for publication September 3, 2013; revision accepted October 24, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Gaia Grassetto, MD, Departments of Imaging, Radiology, Interventional Radiology, Neuroradiology, Nuclear Medicine, Service of Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Viale Tre Martiri 140, 45100 Rovigo, Italy. E-mail:

© 2014 by Lippincott Williams & Wilkins