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Responsiveness of FDG PET/CT to Treatment of Patients With Active Chronic Sarcoidosis

Sobic-Saranovic, Dragana P. MD, PhD*†; Grozdic, Isidora T. MD; Videnovic-Ivanov, Jelica MD, PhD; Vucinic-Mihailovic, Violeta MD, PhD*‡; Artiko, Vera M. MD, PhD*†; Saranovic, Djordjije Z. MD, PhD; Pavlovic, Smiljana V. MD, PhD*†; Obradovic, Vladimir B. MD, PhD*†

doi: 10.1097/RLU.0b013e31828731f5
Original Articles

Purpose This study aimed to compare baseline to follow-up 18F-FDG PET/CT findings after treatment for active chronic sarcoidosis and to correlate changes on 18F-FDG PET/CT with changes in clinical status.

Patients and Methods The sample included 66 patients with chronic sarcoidosis and evidence of active inflammation on baseline 18F-FDG PET/CT for which they received therapy. Of these 66 patients, 30 returned for the follow-up 18F-FDG PET/CT after 12 (5) months to evaluate response to treatment. They were also asked to indicate changes in clinical status. Baseline characteristics of patients who did and did not return for the follow-up were compared to assess selection bias.

Results SUVmax was significantly decreased at the follow-up compared with baseline 18F-FDG PET/CT (8.46 [3.52] vs 4.90 [0.96]; P = 0.006), primarily in the mediastinum. Inflammatory activity appeared absent in 9 patients, decreased in 12 patients, and increased in 9 patients, with the corresponding changes in SUVmax of −80%, −41%, and +54%, respectively. The changes on 18F-FDG PET/CT were in agreement with self-perceived changes in clinical symptoms (P = 0.019). The angiotensin-converting enzyme at the follow-up was not significantly different from baseline (49.80 [19.25] vs 46.35 [25.58], P = 0.522). There was no difference in baseline characteristics of patients who did and did not return for the follow-up.

Conclusions 18F-FDG PET/CT is able to detect clinically meaningful changes in magnitude and extent of inflammatory activity in patients receiving treatment for active chronic sarcoidosis. Thus, 18F-FDG PET/CT is a valuable adjunct to clinical evaluation for monitoring the response to treatment in these patients.

From the *Faculty of Medicine, University of Belgrade; †Center for Nuclear Medicine, ‡Clinic for Pulmology, §Center for Radiology and Magnetic Resonance, Clinical Center of Serbia, Belgrade, Serbia.

Received for publication November 23, 2012; revision accepted January 7, 2013.

Supported by the Serbian Ministry of Education and Science (grants no. 175018, 175046, and 175081).

Conflicts of interest and sources of funding: none declared.

Reprints: Dragana Sobic-Saranovic, MD, PhD, Center for Nuclear Medicine, Clinical Center of Serbia, Visegradska 26 St, 11000 Belgrade, Serbia. E-mail:

© 2013 by Lippincott Williams & Wilkins