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18F-Fluoride PET/CT Aspect of an Unusual Case of Erdheim-Chester Disease With Histologic Features of Langerhans Cell Histiocytosis

Caoduro, Cécile MD*†; Ungureanu, Constantin Marius MD*†; Rudenko, Boris MD; Angoue, Orland MD*†; Blagosklonov, Oleg MD, PhD*†; Paycha, Frédéric MD, PhD§; Boulahdour, Hatem MD, PhD*†

doi: 10.1097/RLU.0b013e318270830f
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We report the case of a 63-year-old woman with Erdheim-Chester disease (ECD) and histologic features of Langerhans cell histiocytosis, both extremely rare histiocytic proliferations responsible of skeletal and extraskeletal involvement. 18F-Fluoride PET/CT revealed multiple intense focal uptake scattered throughout the skeleton. We also performed an 18F-FDG PET/CT which point out visceral and vascular involvement. This case illustrates the interest of PET/CT in ECD, a rare polymorphus and systemic disease, and in our knowledge, this is the first reported illustration of 18F-fluoride PET/CT findings in this pathology.

From the *Universite de Franche-Comte, Besançon; †Nuclear Medicine Department, University Hospital of Besançon, Besançon; ‡Nuclear Medicine Department, Montbéliard Hospital, Montbéliard; and §Nuclear Medicine Department, Lariboisière Hospital, Paris, France.

Received for publication February 24, 2012; and revision accepted August 9, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Cécile Caoduro, MD, Department of Nuclear Medicine, CHU Jean Minjoz, Boulevard Alexandre Fleming, 25030 Besançon, France. E-mail:

© 2013 by Lippincott Williams & Wilkins