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Correlative Imaging With 18F-FDG PET/CT and MRI in Paraneoplastic Limbic Encephalitis

Maffione, Anna Margherita MD*; Chondrogiannis, Sotirios MD*; Ferretti, Alice*; Al-Nahhas, Adil FRCP; Rubello, Domenico MD*

doi: 10.1097/RLU.0b013e318286bda5
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Limbic encephalitis is one of the most common paraneoplastic neurological syndromes, which is mostly associated with small cell lung cancer, testicular tumors, and breast cancer. 18F-FDG PET/CT can have an important role both in the identification of limbic encephalitis itself and in the detection of the unknown malignancy that might have caused it. We report a case of a 57-year-old female patient with paraneoplastic limbic encephalitis, confirmed both by MRI and 18F-FDG PET/CT, and the concurrent identification of an unknown lung malignancy by whole-body PET/CT.

From the *Department of Nuclear Medicine, PET/CT Centre, Santa Maria della Misericordia Hospital Rovigo, Rovigo, Italy; and †Department of Nuclear Medicine, Hammersmith Hospital, London, UK.

Received for publication September 17, 2012; revision accepted December 29, 2012.

Reprints: Anna Margherita Maffione, MD, Santa Maria della Misericordia Hospital Rovigo, Via Tre Martiri 140, 45100 Rovigo, Italy. E-mail:

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