Institutional members access full text with Ovid®

Share this article on:

18F-FDG PET/CT for the Assessment of Disease Extension and Activity in Patients With Sarcoidosis: Results of a Preliminary Prospective Study

Ambrosini, Valentina MD, PhD*; Zompatori, Maurizio MD; Fasano, Luca MD; Nanni, Cristina MD*; Nava, Stefano MD; Rubello, Domenico MD§; Fanti, Stefano MD*

doi: 10.1097/RLU.0b013e31827a27df
Original Articles

Purpose This study aimed to prospectively investigate 18F-FDG PET/CT role for the assessment of sarcoidosis activity and extension in comparison with thoracic high-resolution CT (HRCT) and to evaluate the potential clinical impact of PET/CT findings. Secondary aim was to investigate the changes in cardiac FDG uptake related to the specific preparation before PET/CT.

Methods We prospectively enrolled biopsy proven sarcoidosis patients consecutively referred for 18F-FDG PET/CT since January 2010. PET/CT was performed after a fat meal followed by 12-hour fasting and compared with thoracic HRCT results obtained in supine position and clinical follow-up. The impact on the clinical management was recorded.

Patterns of cardiac FDG uptake of the study group were compared with a historical population in which PET/CT was performed following standard preparation.

Results A total of 28 patients were enrolled, and 35 PET/CT scans were reviewed. On a scan basis, PET/CT was concordant with HRCT in 16 (45.7%), detecting active disease in 10/16 and no signs of activity in 4/16. PET/CT data had a direct impact on management in 4/16.

In 19 (54.3%) discordant scans, PET/CT finding was positive in 14 and negative in 5. PET/CT findings influenced the clinical management in 18/19 cases.

Considering all scans, PET/CT information influenced the clinical management of 22 (63%) of 35.

Our data suggest that cardiac FDG uptake may vary regardless of the preparation before PET/CT.

Conclusions 18F-FDG PET/CT was useful to assess sarcoidosis activity and extension and provided valuable information for the clinical management in a single-step examination. Additional data are needed to better ascertain the optimal patient preparation before image acquisition to improve sensitivity of heart lesions.

From the Departments of *Nuclear Medicine, †Radiology, ‡Respiratory Medicine, Sant’Orsola-Malpighi University Hospital, Bologna; and §Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy.

Received for publication September 7, 2012; revision accepted October 15, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Valentina Ambrosini, MD, PhD, Department of Nuclear Medicine, Pad 30, Azienda Ospedaliero Universitaria di Bologna, Policlinico Sant’Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy. E-mail:

© 2013 by Lippincott Williams & Wilkins