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Presurgical Lateralization of Seizure Focus in Temporal Lobe Epilepsy With Noninvasive Imaging

Pillai, Jay J. MD*; Williams, Hadyn T. MD; Forseen, Scott E. MD; Park, Yong D. MD§

doi: 10.1097/RLU.0b013e31825ae8d0
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We retrospectively compared the seizure focus-localizing capability of interictal PET/CT to that of interictal magnetic resonance diffusion-weighted imaging and ictal SPECT in 21 patient candidate for neurosurgery with temporal lobe epilepsy (TLE) by assessing overall lateralizing ability of these modalities and concordance of findings on these studies with results of electroencephalography (EEG). PET/CT demonstrated the greatest lateralizing ability of any of the imaging modalities and had the highest concordance rate for lateralization with EEG, highlighting its increasing diagnostic utility in the preoperative imaging workup of patients with medically intractable TLE.

From the *Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, MD; †Section of Nuclear Medicine and ‡Division of Neuroradiology, Departments of Radiology and §Neurology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA.

Received for publication December 8, 2011; and revision accepted March 5, 2012.

Presented in part at the 44th Annual Meeting of the American Society of Neuroradiology, April 29 to May 5, 2006, San Diego, Calif.

Conflicts of interest and sources of funding: none declared.

Reprints: Hadyn T. Williams, MD, Department of Radiology, Section of Nuclear Medicine, Medical College of Georgia, Georgia Health Sciences University, 1120 Fifteenth St, BA-1414, Augusta, GA 30912. E-mail:

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