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Peripheral Bone Involvement of Intravascular Large B-Cell Lymphoma on 99mTc-MDP Bone Scan and 18F-FDG PET/CT

Oh, Sun Young, MD; Cheon, Gi Jeong, MD, PhD; Jeong, Eugene, MD; Lee, Sinae, MD; Park, Tae Gyu, MD; Pahk, Kisoo, MD; Choe, Jae-Gol, MD, PhD

doi: 10.1097/RLU.0b013e31825ae70e
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A 64-year-old man was admitted for evaluation of recently developed anemia and bone pain. The bone scan showed diffusely active lesions in the peripheral bones, symmetrically. Interestingly, 18F-FDG PET/CT revealed the hypermetabolic changes in the peripheral bones as well as the internal organs. Biopsy of bone marrow confirmed the diagnosis of intravascular B-cell lymphoma. After the 3 cycles of R-CHOP chemotherapy, 18F-FDG PET/CT showed improvement of the previous hypermetabolic lesions, suggesting good response. Intravascular B-cell lymphoma is a rare and aggressive variant of diffuse large cell lymphoma characterized by proliferation of malignant cells within the vascular lumina.

From the Department of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Received for publication October 21, 2011; revision accepted March 12, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Gi Jeong Cheon, MD, PhD, Department of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, 5 ga, Anam-dong, Seongbuk-gu, Seoul, 136-705, Korea. E-mail: larrycheon@gmail.com.

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