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Yttrium-90 Time-of-Flight PET/CT Is Superior to Bremsstrahlung SPECT/CT for Postradioembolization Imaging of Microsphere Biodistribution

Kao, Yung Hsiang, MBBS, MRCP(UK); Tan, Eik Hock, MBBS, FRCR(UK), FAMS; Ng, Chee Eng, MBBS, MRCP(UK), FAMS, MSc; Goh, Soon Whatt, MBBS, MSc, FAMS

doi: 10.1097/RLU.0b013e31821c9a11
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Yttrium-90 (Y-90) has internal pair production that can be imaged by PET/CT. Y-90 PET/CT has better spatial resolution than bremsstrahlung SPECT/CT, and it is possible to use Y-90 PET/CT for accurate postradioembolization imaging of hepatic microsphere biodistribution. Y-90 time-of-flight PET/CT represents the current state-of-the-art in postradioembolization imaging. We present a case of Y-90 time-of-flight PET/CT scan performed after Y-90 selective internal radiation therapy in a 62-year-old man, depicting hepatic microsphere biodistribution in high resolution.

From the Department of Nuclear Medicine and PET, Singapore General Hospital, Singapore.

Received for publication January 10, 2011; revision accepted March 14, 2011.

This manuscript is the original work of all the authors. We have reviewed the final version, and we approve it for publication. This manuscript has not been previously published, nor is it being considered for publication elsewhere.

This report adheres to the ethical standards of our institution.

Conflicts of interests and sources of funding: none declared.

Reprints: Yung Hsiang Kao, Department of Nuclear Medicine & PET, Singapore General Hospital, Outram Rd, Singapore 169608. E-mail:

Copyright © 2011 Wolters Kluwer Health, Inc. All rights reserved.