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Extramedullary Gastric Relapse of Acute Lymphoblastic Leukemia Following Allogeneic Stem Cell Transplant: Staging With F-18 FDG PET/CT

Ciarallo, Anthony MD*; Makis, William MD; Novales-Diaz, Javier-A. MD*; Michel, René P. MD

doi: 10.1097/RLU.0b013e318217af1c
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A 26-year-old man with a prior history of acute leukemia that was treated with a stem cell transplant (SCT) was referred for an F-18 FDG PET/CT to assess suspicious new gastric mucosal lesions. The lesions were FDG-avid and were histologically proven to be acute lymphoblastic leukemia (ALL). Extramedullary relapse of ALL after SCT is very rare, with only 60 cases reported in the literature, and the role of F-18 FDG PET/CT in monitoring for ALL relapse following SCT has not been previously investigated. This rare case report highlights the use of F-18 FDG PET/CT in staging gastric relapse of ALL following SCT.

From the *Department of Nuclear Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada; †Department of Nuclear Medicine, Brandon Regional Health Centre, Brandon, Manitoba, Canada; and ‡Department of Pathology, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

Received for publication October 11, 2010; revision accepted December 26, 2010.

This manuscript or any containing figures or tables have not been submitted to any publication previously. None of the authors have any financial or other relationships that might lead to a conflict of interest. The manuscript has been read and approved by all the authors, and the requirements for authorship have been met. Each author believes that the manuscript represents honest work.

Reprints: William Makis, MD, Director, Department of Nuclear Medicine, Brandon Regional Health, 150 McTavish Ave E, Brandon, Manitoba R7A 2B3, Canada. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.