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Multimodality Imaging in a Patient With Adrenocortical Carcinoma Leading to Peptide Receptor Radionuclide Therapy

Andersen, Kim Francis, MD*; Mellemgaard, Anders, MD; Hendel, Helle Westergren, MD, PhD*

doi: 10.1097/RLU.0b013e3181abb74e
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In the recommended staging system for adrenocortical carcinoma, nuclear medicine modalities are optional. In cases of distorted postoperative anatomy and when postoperative infection/inflammation mimics malignancy, functional imaging is helpful. We present a case of a patient with adrenocortical carcinoma where F-18 FDG dual time point imaging and somatostatin receptor scintigraphy were used in the diagnostic work up after surgery complicated by infection, until end-stage palliative peptide receptor radionuclide therapy. The estimated uptake on somatostatin receptor scintigraphy is traditionally done visually on planar images. We suggest a more objective, semiquantitative approach by comparing the tumor uptake with a standard reference.

From the Departments of *Clinical Physiology and Nuclear Medicine, and †Oncology, Herlev Hospital, University Hospital of Copenhagen, Herlev, Denmark.

Received for publication January 8, 2009; accepted April 7, 2009.

Reprints: Kim Francis Andersen, MD, Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University Hospital of Copenhagen, DK-2730, Herlev, Denmark. E-mail:

© 2009 Lippincott Williams & Wilkins, Inc.