Interesting ImageDelayed Acquisition and Hyperglycemia Improve Brain Metastasis Detection on F-18 FDG PETFarid, Karim MD*†‡¶; Sibon, Igor MD, PhD*†‡; Fernandez, Philippe MD, PhD†‡§; Guyot, Martine MD†; Jeandot, Roseline MD†‡; Allard, Michele MD, PhD*†‡ Author Information From the *Centre national de la recherche scientifique-UMR 5231, Bordeaux, France; †Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France; ‡Université Bordeaux 2, Bordeaux, FRANCE; §Inserm, U577, Bordeaux, France; and ¶Hôpital Hôtel Diev de Paris, Assistance Publique des Hopitaux de Paris, Paris, France. Received for publication August 5, 2008; accepted March 27, 2009. Reprints: Farid Karim, MD, Department of nuclear medicine, Hôpital Pellegrin, C Centre Hospitalier Universitaire Bordeaux, Place Amélie Raba Léon, 33076 Bordeaux, France. E-mail: [email protected]. Clinical Nuclear Medicine: August 2009 - Volume 34 - Issue 8 - p 533-534 doi: 10.1097/RLU.0b013e3181abb67e Buy Metrics Abstract A 60-year-old man with a history of lung cancer was admitted for a first partial epileptic seizure. Brain MRI demonstrated a right frontal lesion evoking a metastasis. F-18 FDG-PET-CT revealed this lesion only on delayed images obtained after oral hyperglycemia. Increased plasma glucose levels and delayed image acquisition both, independently, increased the F-18 FDG-PET tumor-to-cortex binding ratio and have been shown to improve the detection of primary brain tumor recurrences. This single case illustrates that delayed acquisition combined with hyperglycemia might improve the sensitivity of F-18 FDG-PET imaging in the detection of brain metastases. Further studies are needed to confirm this result. © 2009 Lippincott Williams & Wilkins, Inc.