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Splenic Infarction Mimicking a Necrotizing Metastasis of Malignant Melanoma on F-18 FDG PET/CT

Ahmadzadehfar, Hojjat MD*; Brockmann, Holger MD*; Schmiedel, Alexandra MD; Biersack, Hans-Jürgen MD*; Ezziddin, Samer MD*

doi: 10.1097/RLU.0b013e31817dec28
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A 67-year-old woman with a history of malignant melanoma in the right lower leg for 7 years without any known metastases was hospitalized for evaluation of severe left upper quadrant abdominal pain. Computed tomography of the abdomen revealed a suspected splenic mass. F-18 FDG PET/CT imaging showed a large photopenic area in the same region surrounded by a circular area of high FDG uptake. It could not be definitely differentiated between a splenic infarction and a necrotizing metastasis of malignant melanoma or other malignancies. Subsequent splenectomy revealed an infected splenic infarction.

From the Departments of *Nuclear Medicine; and †Department of Radiology, University of Bonn, Bonn, Germany.

Received for publication October 5, 2007; revision accepted March 5, 2008.

Reprints: Hojjat Ahmadzadehfar, MD, Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. E-mail: or

© 2008 Lippincott Williams & Wilkins, Inc.