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Fluorouracil-induced Hepatic Artery Spasm Preventing Yttrium-90 Microsphere Administration

Townsend, Amanda, MBBS; Price, Timothy J., MBBS, FRACP; Patterson, Kevin, MBBS, FRACP; Pittman, Ken, MBBS, MD, FRACP

doi: 10.1097/RLU.0b013e31817deaeb
Original Article

Coronary spasm is a recognized complication of fluorouracil (FU) chemotherapy. Spasm has been documented at other arterial sites with FU. SIR-spheres (radioactive yttrium-90 microspheres) are increasingly being used for hepatic colorectal metastasis. Various FU schedules are reported in the literature, and it is likely there will be coadministration with SIR-spheres. There is, however, little specific information in these reports as to the timing of FU and hepatic arterial spasm associated with infusion FU, which is a potential complication that should be considered.

From the Department of Oncology, The Queen Elizabeth Hospital, Woodville Road, Woodville, South Australia.

Received for publication August 29, 2007; accepted April 14, 2008.

Reprints: Timothy Price, MBBS, FRACP, Department of Oncology, The Queen Elizabeth Hospital, Woodville Rd, Woodville, South Australia 5011. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.