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Extramedullary Hematopoiesis on F-18 FDG PET/CT in a Patient With Metastatic Colon Carcinoma

Mosley, Christopher, MD*; Jacene, Heather A., MD; Holz, Andrew, MD; Grand, David J., MD§; Wahl, Richard L., MD

doi: 10.1097/RLU.0b013e318156bc84
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A 43-year-old Kuwaiti man with a history of β-thalassemia intermedia was diagnosed with lymph node-positive sigmoid adenocarcinoma and underwent left hemicolectomy. He had multiple paraspinal masses and a right middle lobe lung nodule on CT scan. F-18 FDG PET/CT imaging revealed intense metabolic activity within the pulmonary nodule and subsequent biopsy revealed metastatic adenocarcinoma. The PET/CT scan also revealed mild to moderate FDG activity in multiple paraspinal thoracic masses. MRI findings were most consistent with multiple sites of extramedullary hematopoiesis.

From the *Department of Nuclear Medicine, Emory University/Atlanta VA Medical Center, Atlanta, GA; †Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD; and †Department of Diagnostic Imaging, Brown Medical School, Providence, RI.

Received for publication January 29, 2007; revision accepted June 27, 2007.

Reprints: Christopher Mosley, MD, Atlanta VA Medical Center/Emory University, Department of Nuclear Medicine, 1670 Clairmont Rd., Decatur, GA, 30033. E-mail: cmosley7@yahoo.com.

© 2007 Lippincott Williams & Wilkins, Inc.