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False-Positive Uptake of FDG in Hepatic Sarcoidosis

Guglielmi, Andrew N., DO*; Kim, Benedict Y., DO*; Bybel, Bohdan, MD; Slifkin, Nancy, RT

Clinical Nuclear Medicine: March 2006 - Volume 31 - Issue 3 - p 175
doi: 10.1097/01.rlu.0000200927.43663.fc
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Positron emission tomography (PET), with the use of F-18 fluorodeoxyglucose (FDG), has been shown to be useful in the evaluation of many tumors as a result of its high sensitivity and specificity. There are instances, however, in which false-positive FDG uptake can occur with inflammatory lesions or granulomatous diseases. In fact, false-positive mediastinal uptake in thoracic sarcoidosis has been well documented. We present a case of false-positive FDG uptake in the liver resulting from hepatic sarcoidosis. A 42-year-old, asymptomatic woman underwent a PET scan after a solitary pulmonary nodule was detected on a chest CT. The nodule in the left lower lobe on CT revealed no metabolic activity, but 2 lesions were found in the liver with SUVs in the range of 2.5 to 3.2. A subsequent MRI was not able to exclude malignancy. The liver lesions were surgically removed and found to be sarcoidosis.

From the *Department of Radiology, Aultman Hospital/Northeastern Ohio University College of Medicine, Canton, OH; the †Department of Nuclear Medicine, The Cleveland Clinic Foundation, Cleveland, OH; and ‡Alliance Community Hospital, Alliance, OH.

Received for publication August 25, 2005; revision accepted October 24, 2005.

Reprints: Andrew N. Guglielmi, DO, Aultman Hospital, Department of Radiology, 2600 Sixth St. SW, Canton, OH 44710. E-mail:

© 2006 Lippincott Williams & Wilkins, Inc.