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C–11 Methionine Uptake in Granulomatous Disease

Hain, Sharon F., MBBS, FRACP; Beggs, Andrew D., MBBS, BSc

doi: 10.1097/01.rlu.0000134997.91642.56
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Although uptake of F-18 FDG is well documented in granulomatous disease, there is little literature available regarding C-11 methionine positron emission tomography (PET) in these conditions. We present a case in which C-11 methionine imaging was performed for localization of a probable parathyroid adenoma, but other areas of uptake identified were subsequently found to be the result of sarcoidosis. Clinicians must therefore take care when interpreting C-11 methionine PET scans because granulomatous disease could cause false-positives.

From The Clinical PET Centre, Guys & St. Thomas’ Hospitals, Lambeth Palace Road, London, UK.

Received for publication September 3, 2003; revision accepted December 23, 2003.

Reprints: Sharon F. Hain, MBBS, FRACP, The Clinical PET Centre, Guys & St. Thomas’ Hospitals, Lambeth Palace Road, London, SE1 7EH, UK. E-mail: sharon.hain@kcl.ac.uk

© 2004 Lippincott Williams & Wilkins, Inc.