Interesting ImageDemonstration of Increased FDG Activity in Rosai-Dorfman Disease on Positron Emission TomographyYu, Jian Q., MD; Zhuang, Hongming, MD, PhD; Xiu, Yan, MD; Talati, Erin, BA; Alavi, Abass, MDAuthor Information From the Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Received for publication July 8, 2003; accepted August 8, 2003. Reprints: Hongming Zhuang, MD, PhD, Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 110 Donner Building, 3400 Spruce Street, Philadelphia, PA 19104; E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: March 2004 - Volume 29 - Issue 3 - p 209-210 doi: 10.1097/01.rlu.0000114018.07676.15 Buy Metrics Abstract Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy, is a rare benign disease of unknown etiology that most commonly involves the cervical lymph nodes. Imaging with F-18 positron emission tomography (FDG-PET) has been widely accepted as an important diagnostic modality in the evaluation of patients with possible cancers. However, FDG is not a tumor-specific tracer, and numerous nonmalignant processes can result in increased FDG accumulation. We report the detection of Rosai-Dorfman disease by FDG-PET in a patient with suspected metastatic breast cancer. © 2004 Lippincott Williams & Wilkins, Inc.