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Tc-99m MIBI, Tc-99m Tetrofosmin, and Tc-99m (V) DMSA Accumulation in Recurrent Malignant Thymoma

JANG KIM, SEONG, M.D.; KIM, IN JU, M.D., AND; KIM, YONG KI, M.D.

Original Articles
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Thymoma is the most common primary tumor of the anterior mediastinum, accounting for 20% to 30% of all mediastinal tumors. The recurrence rate after total resection of the thymoma ranges from 8% to 18%. The authors describe a patient with recurrent malignant thymoma imaged with Tc-99m MIBI, Tc-99m tetrofosmin, and Tc-99m (V) DMSA. Early and delayed Tc-99m MIBI and Tc-99m tetrofosmin scintigraphy showed increased uptake in the mediastinal area, as did Tc-99m (V) DMSA scintigraphy. Coronal SPECT images obtained with Tc-99m MIBI, Tc-99m tetrofosmin, and Tc-99m (V) DMSA showed increased uptake in the mediastinal lesion seen on a computed tomograph of the chest. However, the normal blood-pool activity of the heart and great vessels imaged with Tc-99m (V) DMSA obscured the recurrent malignant thymoma. Although Tc-99m (V) DMSA is a useful tumor-seeking agent, Tc-99m MIBI and Tc-99m tetrofosmin SPECT are preferred to Tc-99m (V) DMSA to detect primary and recurrent malignant thymoma.

From the Department of Nuclear Medicine, College of Medicine, Pusan National University, Pusan, Korea

Received for publication December 20, 2000.

Accepted April 12, 2001.

Reprint requests: In Ju Kim, Department of Nuclear Medicine, College of Medicine, Pusan National University, 1 Ga 10, Ami-Dong, Seo-Gu, Pusan, Korea 602-739. E-mail: injkim@hyowon.cc.pusan.ac.kr

© 2002 Lippincott Williams & Wilkins, Inc.