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Pleomorphic Liposarcoma Metastatic to the Thyroid Gland

BASHIR, HUMAYUN, M.B.B.S.*; KHALID NAWAZ, M., M.B.B.S., M.Sc., K.B.N.M.*; SHAH, MAZHAR A., M.B.B.S., D.M.R.T.; AHMAD, EJAZ, M.D.

Original Articles
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Although carcinoma is rarely metastatic to the thyroid gland, it has an established place in the differential diagnosis of cold nodules on radionuclide thyroid scans in patients with known cancers. A case of metastatic pleomorphic liposarcoma with involvement of the thyroid gland adds to the list of cases of metastases to the thyroid gland. A patient with known metastatic pleomorphic liposarcoma with a palpable thyroid nodule of 2 months’ duration had a thyroid scan with 130 MBq (3.5 mCi) Tc-99m pertechnetate. The scan showed a cold nodule occupying most of the right lobe of the thyroid. Cytologic analysis of a fine-needle aspirate from this cold nodule confirmed metastasis from the known primary cancer, pleomorphic liposarcoma. In a patient with a known primary tumor, a nodule in the thyroid gland should be considered a metastatic lesion, regardless of the time since the primary tumor was diagnosed and treated, until proved otherwise.

From the Departments of Nuclear Medicine,* Radiation Oncology,† and Pathology,‡ Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan

Received for publication July 19, 2001.

Accepted August 22, 2001.

Correspondence: Dr. Muhammad Khalid Nawaz, Nuclear Medicine Department, Shaukat Khanum Memorial Cancer Hospital and Research Center, P.O. Box 13014, Lahore, Pakistan. E-mail: khalid@skm.org.pk

© 2002 Lippincott Williams & Wilkins, Inc.