Although carcinoma is rarely metastatic to the thyroid gland, it has an established place in the differential diagnosis of cold nodules on radionuclide thyroid scans in patients with known cancers. A case of metastatic pleomorphic liposarcoma with involvement of the thyroid gland adds to the list of cases of metastases to the thyroid gland. A patient with known metastatic pleomorphic liposarcoma with a palpable thyroid nodule of 2 months’ duration had a thyroid scan with 130 MBq (3.5 mCi) Tc-99m pertechnetate. The scan showed a cold nodule occupying most of the right lobe of the thyroid. Cytologic analysis of a fine-needle aspirate from this cold nodule confirmed metastasis from the known primary cancer, pleomorphic liposarcoma. In a patient with a known primary tumor, a nodule in the thyroid gland should be considered a metastatic lesion, regardless of the time since the primary tumor was diagnosed and treated, until proved otherwise.
From the Departments of Nuclear Medicine,* Radiation Oncology,† and Pathology,‡ Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan
Received for publication July 19, 2001.
Accepted August 22, 2001.
Correspondence: Dr. Muhammad Khalid Nawaz, Nuclear Medicine Department, Shaukat Khanum Memorial Cancer Hospital and Research Center, P.O. Box 13014, Lahore, Pakistan. E-mail: email@example.com