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Uptake of In-111 Pentetreotide by Normally Functioning Nodular Goiters

GARANCINI, SILVANA, M.D.*; LA ROSA, STEFANO, M.D.; DE PALMA, DIEGO, M.D.*; UCCELLA, SILVIA, M.D.; GOLONIA, FABRIZIO, M.D.

Original Article
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After the intravenous administration of a radiolabeled somatostatin analogue (octreotide), normal thyroid and neoplastic and nonneoplastic thyroid lesions can be visualized. The authors present the cases of two patients who underwent somatostatin receptor scintigraphy(SSRS) using In-111 pentetreotide: one for the study of suspected paraneoplastic ACTH hypersecretion, and the other for a restaging of breast carcinoma with neuroendocrine features. In both patients, SSRS revealed increased uptake in the thyroid, corresponding to "cold" nodules on Tc-99m pertechnetate imaging. Cytologic and histologic examinations showed the typical features of thyroid goiters without lymphocytic infiltration.

From the Nuclear Medicine Service,* Ospedale di Circolo, the Department of Clinical and Biological Sciences,† University of Pavia at Varese, and the Department of Internal Medicine,‡ Ospedale di Circolo, Varese, Italy

Received for publication February 11, 1997; accepted April 2, 1997.

Reprint requests: Silvana Garancini, M.D., Nuclear Medicine Service, Ospedale di Circolo, Viale Borri, 57-I21100, Varese, Italy.

© Lippincott-Raven Publishers