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Unexpected Pulmonary Clumping of In-111 Leukocytes Attributable to Indium Oxine Reagent

BOHDIEWICZ, PAUL J., M.D.*; FINK-BENNETT, DARLENE, M.D.*; NAGLE, CONRAD, M.D.; ABGHARI, REZA, M.D.; GUTKOWSKI, ROBERT*; DWORKIN, HOWARD J., M.D.*

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Five cases of artifactual In-111 leukocyte pulmonary activity were noted at three local hospitals in a 4-day period. Based on the differences in the preparation of the final indium leukocyte product, the problem could be attributed to the indium oxine reagent in a specific lot. This artifact of multiple small foci of marked increased activity in the lungs (clumping pattern), attributable to the In-111 oxine reagent, has not been described previously.

*From the Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan

†From the Department of Nuclear Medicine, William Beaumont Troyt, Michigan

‡From the Department of Nuclear Medicine, Oakwood Hospital, Dearborn, Michigan

© Lippincott-Raven Publishers.