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Comparative SPECT Study of Stroke Using Tc-99m ECD, I-123 IMP, and Tc-99m HMPAO

MATSUDA, HIROSHI, M.D.*; LI, YA MING, M.D.*; HIGASHI, SOTARO, M.D.; SUMIYA, HISASHI, M.D.*; TSUJI, SHIRO, M.D.*; KINUYA, KEIKO, M.D.*; HISADA, KINICHI, M.D.*; YAMASSHITA, JUNKOH, M.D.

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Brain perfusion SPECT imaging using Tc-99m ethyl cysteinate dlmer (ECD) was carried out in 12 patients with chronic cerebrovascular disease. The sensitivity of lesion detection and lesion-to-normal tissue contrast was compared with those of I-123 IMP and Tc-99m HMPAO. Eight patients underwent all three studies and the remaining four patients had Tc-99m ECD and I-123 IMP scans. The sensitivity of lesion detection and lesion contrast was analyzed quantitatively using an asymmetric index determined by the equation: 100 x I |right - left| l/ (right + left). In the cerebral cortex, cerebellum, and white matter, I-123 IMP showed higher lesion sensitivity than Tc-99m ECD and Tc-99m HMPAO. In the striatum and thalamus, Tc-99m ECD and I-123 IMP showed higher lesion sensitivity than Tc-99m HMPAO. I-123 IMP showed the highest lesion contrast in cerebral cortex and cerebellum, whereas Tc-99m ECD showed the highest contrast in thalamus and striatum. In all regions, Tc-99m ECD showed higher lesion contrast than Tc-99m HMPAO. These results suggest regional variation in the sensitivity of lesion detection and lesion contrast of Tc- 99m ECD compared to I-123 IMP, and the superiority of Tc-99m ECD to Tc-99m HMPAO

*From the Departments of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan

†From the Departments of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan

© Lippincott-Raven Publishers.