TI-201 chloride bone scans were performed on nine patients with primary hyperparathyroidism just after TI-201 and Tc-99m parathyroid subtraction scintigraphy. Bone lesions accumulate TI-201, especially in sites of brown tumor formation. This was proven by the histopathologic examination of two patients. Eight patients had bone scans with Tc-99m MDP. The lesion-to-background ratio was quantified in seven patients for TI-201 and in four patients for Tc-99m MDP. TI-201 uptake of the lesions were quantified in two patients. The lesion-to-background ratio was 1.63 ± 0.21 and 2.51 ± 0.88 for TI-201 and Tc-99m MDP, respectively. A Ga-67 citrate scan was performed on one patient, and the lesion-to-background ratio was 1.49 ± 0.06. The accumulation of TI-201 in brown tumors of bone might be due to increased blood flow and local metabolic activity. TI-201 chloride was inferior to Tc-99m MDP in lesion detection. It is concluded that bone imaging with TI-201 can easily be performed following parathyroid subtraction scintigraphy to delineate the sites of brown tumor formation.
*Department of Nuclear Medicine, Eylul University, Izmir
†Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey
‡Department of Internal Medicine, Hacettepe University, Ankara, Turkey