The authors retrospectively reviewed the Tc-99m medronate scan findings in six patients who had no evidence of metastatic disease following en bloc resection of a primary osteosarcoma and subsequent limb reconstruction using allograft bone. Persistently increased radionuclide uptake was noted at the junction between the host bone and the graft, while the graft cortical bone showed persistently decreased activity. Radionuclide uptake at the periphery of the graft varied. Over time the youngest patient in the series had increasingly normal scan findings.
*Department of Diagnostic Radiology and Nuclear Medicine, Stanford University School of Medicine, Stanford
‡Radiation Therapy, Stanford University School of Medicine, Stanford
§;Orthopaedic Surgery, Stanford University School of Medicine, Stanford
Department of Orthopaedic Surgery,† University of California, San Francisco, California