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Reduced Uptake of Bone-Seeking Radiopharmaceuticals Related to Iron Excess

Parker, J. Anthony*; Jones, Alun G.; Davis, Michael A.; Mcilmoyle, Gaellan; Tow, Donald E.

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A suggestive relationship between the degree of iron overload and decreased skeletal uptake of phosphorus containing bone seeking radiopharmaceuticals was noted in four patients. It is postulated that iron excess may affect the organ distribution of bone seeking radiopharmaceuticals (phosphates and phosphonates) and that iron overload may account for some of the poor quality of bone scans seen clinically.

From the Department of Radiology, Division of Nuclear Medicine, Harvard Medical School and The Nuclear Medicine Units, Mount Auburn Hospital and West Roxbury Veterans Administration Hospital, Boston, Massachusetts

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