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The effect of ibuprofen on muscle, hematological and renal function, hydric balance, pain, and performance during intense long-distance running

Fabricio de Souza, Raphael1,2,3,5; Gama de Matos, Dihogo2; Pires Ferreira, Alexandre Reis1,2; Chilibeck, Philip6; de Almeida Barros, Natalie2,4; Santos de Oliveira, Alan7; Cercato, Luana Mendonça7; Soares da Silva, Danielle8; Aidar, Felipe José1,2,3,4

The Journal of Strength & Conditioning Research: February 14, 2018 - Volume Publish Ahead of Print - Issue - p
doi: 10.1519/JSC.0000000000002502
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The aim of this study was to investigate the effect of prophylactic use of nonsteroidal anti-inflammatory drugs (NSAID, i.e. Ibuprofen) on physical performance, vertical jump, muscle biomarkers, liver, kidney, acute pain and hydration status of participants in the 42 km Trail Running Challenge, a long-distance race integrated over mountain routes. The sample consisted of 20 males randomly divided into two groups: a control group (CG) and an experimental group (EG) with 12 completing the race (41.1±8.8 y; 75.7±12.1 kg) and included in the final analysis. The EG were administered an ibuprofen capsule (400 mg) fifteen minutes before the beginning of the race, and again after 5 hours of racing if the route was not yet complete. There were significant time main effects for creatine kinase (CK) (p=0.001; f2 Cohen=0.25), lactate dehydrogenase (LDH) (p<0.001; f2 Cohen=2.05), aspartate aminotransferase (AST) (p=0.002; f2 Cohen=1.53), creatinine (p=0.002; f2 Cohen=2.24), urea (p=0.001; f2 Cohen=2.25), heart rate (HR) (p<0.001; f2 Cohen=4.88) and pain scores (p<0.001; f2 Cohen=1.93) which all increased during the race. There was a group × time interaction for squat jump (SJ) which significantly decreased in only the CG (p= 0.045; f2 Cohen=2.17). This may have been related to increased frequency of pain reported after the race in the gastrocnemius of the CG compared to the EG (p<0.05). It was concluded that ibuprofen intake did not reduce muscle damage during the competition but maintained leg muscular power performance (i.e. vertical jump), possibly by reducing gastrocnemius muscle pain.

1Department of Physical Education, Federal University of Sergipe - UFS, São Cristovão, Sergipe, Brazil.

2Group of Studies and Research of Performance, Sport, Health and Paralympic Sports - GEPEPS, the Federal University of Sergipe - UFS, São Cristovão, Sergipe, Brazil

3Racing Club at the Federal University of Sergipe - UFS, São Cristovão, Sergipe, Brazil

4Graduate Program in Master's level in Physical Education, Federal University of Sergipe - UFS, São Cristovão, Sergipe, Brazil

5Graduate Program in Doctor's level in Neuropsychiatry and Behavioral Sciences, Federal University of Pernambuco - UFPE, Recife, Pernambuco, Brazil

6College of Kinesiology, University of Saskatchewan, Saskatoon, Canada

7Department of physiology and pharmacology Inflammatory Process, Federal University of Sergipe - UFS, São Cristovão, Sergipe, Brazil

8Research center and attention to worker health, Federal University of Sergipe - UFS, São Cristovão, Sergipe, Brazil

Raphael Fabrício de Souza Cidade Universitária Prof. José Aloísio de Campos Av. Marechal Rondon, s/n Jardim Rosa Elze CEP 49100-000 São Cristóvão/SE (79) 2105-6600, (79) 2105-6537 dihogogmc@hotmail.com

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