Moraes, RF, Ferreira-Júnior, JB, Marques, VA, Vieira, A, Lira, CAB, Campos, MH, Freitas-Junior, R, Rahal, RMS, Gentil, P, and Vieira, CA. Resistance training, fatigue, quality of life, anxiety in breast cancer survivors. J Strength Cond Res 35(5): 1350–1356, 2021—Resistance training (RT) has shown to be effective in improving fatigue, quality of life (QOL), and anxiety levels among breast cancer survivors (BCS), but there is no consensus as to how this practice should be prescribed for optimal performance. This study analyses the effects of once weekly RT on fatigue, QOL, and anxiety levels among BCS. Randomized controlled trial. Twenty-five BCS (aged 54.6 ± 5.5 years) were randomized into RT or control groups. The RT group performed 8 weeks of RT (once per week). Fatigue was assessed using the Piper Fatigue scale, QOL was assessed using the SF-36, and anxiety was assessed using the STAI State-Trait Anxiety Inventory. Resistance training significantly improved the following subscales of SF-36: aspects of physical functioning (+27%, p = 0.027); physical role functioning (+54%, p = 0.008); emotional role functioning (+42%, p = 0.027); and mental health (+16%, p = 0.032). Furthermore, RT improved fatigue levels (−55%, p = 0.001 for general fatigue) and anxiety (anxiety state, −19%, p = 0.012; anxiety trait, −23%, p = 0.001). Resistance training seemed to be a positive nonpharmacological tool for the reduction of fatigue, anxiety, and for improvement of several aspects of QOL in BCS.