Literature has clearly demonstrated that in a population with some resistance training experience, performing multiple sets per training session of a resistance exercise is superior to performing a single set for eliciting strength. It is less clear, however, whether this remains true in measures other than those specifically targeted in training. The purpose of this study was to examine whether training at a specific isokinetic speed had different carryover effects to other speeds when comparing single set and multiple set protocols. Forty subjects were randomly assigned into one of three groups: control (C; n = 8), single set (SS; n = 14), or multiple sets (MS; n = 18) to perform 8 maximal knee extensions at 60 d/s on an Biodex System 3 isokinetic dynamometer twice a week for eight weeks. The SS group performed one set while the MS group performed three sets. All groups were tested pre, mid (4 weeks), and post at 30, 60, and 180 d/s. Strength was expressed as peak torque (PT). A 3×3×3 (Time × Group × Speed) mixed factor repeated measures ANOVA revealed a Group × Time × Speed interaction. The MS group demonstrated significant (p < 0.05) increases in strength at all three speeds. Pre-testing was not different from mid-testing but was different from post-testing at 30 d/s (Pre = 209.23 + 72.99 Nm; Mid = 218.92 + 73.79 Nm; Post = 232.93 + 83.46 Nm). At 60 d/s, strength increased from pre to mid-testing with no further significant strength gain from mid to post-testing (Pre = 188.32 + 63.06 Nm; Mid = 208.01 + 72.12 Nm; Post = 215.10 + 78.81 Nm). This trend was the same for the MS group at 180 d/s (Pre = 138.76 + 45.41 Nm; Mid = 149.96 + 53.92 Nm; Post = 151.12 + 51.71 Nm). Neither the C nor SS groups demonstrated any change in strength across any time at any speed. It was concluded that performing multiple sets of isokinetic knee extension was superior to performing a single set for eliciting strength at the training speed, as well as across other speeds tested. Multiple sets of resistance exercises have been demonstrated more effective for increasing strength than single sets. The current study suggests that this principle is not necessarily specific to the training velocity, but may include a spectrum of speeds.