This study evaluated the effect of remote voluntary contractions (RVC) on peak torque, rate of torque development, power, and work, the activation of the involved muscles, and gender differences therein. Eleven men and 12 women performed isokinetic knee extension and flexion tests on a dynamometer in RVC and normal (NO-RVC) test conditions. The RVC condition included jaw clenching, hand gripping, and the Valsalva maneuver. Electromyography (EMG) was used to quantify muscle activation. A two way mixed ANOVA with repeated measures for test condition was used to evaluate the main effects for peak torque, rate of torque development, power, and work, as well as the EMG of the prime movers, their antagonist, and muscles involved in the RVCs, and the interaction between test condition and gender. Subjects produced higher mean peak torque, rate of torque development, power, and work in the RVC condition for all tests, with significant differences for 6 of the 8 outcome variables for men (p ≤ 0.05) and 2 or the 8 outcome variables for women (p ≤ 0.05). Significant interactions between test condition and gender indicate differences in response to RVCs during knee extension tests for power (p ≤ 0.01) and work (p ≤ 0.02), and for knee flexion tests for peak torque (p ≤ 0.03) and power (p ≤ 0.049). Prime mover activation was greater in the RVC condition for most tests (p ≤ 0.05). Gender difference in the activation of the left and right flexor digitorum longus during all tests (p ≤ 0.05) suggest that the comparatively lower response of women during the CAP condition may be due to gender differences in hand gripping RVCs. Remote voluntary contractions result in statistically significant enhancement of performance of 6.2 to 12.5% for men and 3.3 to 4.2% for women, for a number of outcome variables assessed, which coincides with remote muscle activation and the concomitant increase in EMG of the prime mover. Athletes and exercisers may attain enhanced strength performance and muscle activation of prime movers by incorporating RVC's into their training.