While it is recognized that muscle contraction results in elevated glucose uptake, there is little application of this concept in exercise prescription. Previous investigations have determined that high resistance training results in greater glucose uptake, compared to low resistance training; while performing the same amount of total work. However, there is little information regarding glucose uptake following cardiovascular exercise when performed at different intensities. The purpose of this study was to investigate the differences in glucose uptake between high intensity interval aerobic exercise and low intensity sustained aerobic exercise, while keeping work the same between trials. 19 college aged males participated in a high intensity interval sprint trial and an endurance trial on separate days. Trials were performed at least 3 days apart, and were performed in a repeated random order. Immediately post exercise, subjects drank a high carbohydrate solution. Blood glucose levels were recorded until they returned to baseline or until 1.5 hours post exercise. Glucose area under the curve was calculated and a paired T-test was used to determine differences. High intensity interval aerobic exercise resulted in significantly greater glucose uptake post exercise compared to low intensity sustained aerobic exercise (p = .037). High intensity intermittent exercise is better at regulating glucose uptake than low intensity sustained aerobic exercise of equal work. We propose that increased attention be given to the “type of exercise” in regulation of blood glucose, rather than strictly “exercise”. It appears that “how” you run, bike, or swim when performing your daily exercise is important in populations attempting to regulate blood glucose levels.