Exergaming is a relatively new area of entertainment that couples physical activity and video gaming. To date, research that has focused on the physiological responses to Exergaming has been focused exclusively on aerobic-type activities. The purpose of this project was to describe the acute exercise responses (i.e. o2, Heart Rate, & RPE) to Exergaming using full-body isometric muscle resistance, and to determine whether these responses are different during single versus opponent based play. Male subjects (n = 32) were randomly and equally divided into either an Experimental (EXP) or Control (CON) group. Acute exercise responses (o2, Heart Rate, and RPE) were measured in all subjects during both solo and opponent-based video game play. Subjects in the EXP group played using a game controller that relied on full body isometric muscle resistance to manipulate the on screen character, while CON subjects used a conventional hand held controller. There were no differences in the exercise response within groups between single and competitive play. Results between groups during solo play are presented in the following table, and are expressed as means±SD. These results suggest that whole body isometric exergaming results in greater energy expenditure than conventional video gaming, with no increase in perceived exertion during play. This could have important implications regarding long term energy expenditure in gamers. The results of this study provide support for the use of low intensity isometric activity as a viable means of increasing energy expenditure during video gaming.