Neurology News

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Tuesday, December 3, 2013

NIH Releases First Set of Genomic Sequencing Data for Alzheimer's

The first batch of genome sequence data from the Alzheimer’s Disease Sequencing Project (ADSP) is now available free of charge to researchers, the National Institutes of Health announced yesterday. These data include genomic information from 410 individuals in 89 families. Researchers can access the sequence data at dbGaP or the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS),

     In a press release, NIH Director Francis S. Collins, MD, PhD, said: “Providing raw DNA sequence data to a wide range of researchers proves a powerful crowd-sourced way to find genomic changes that put us at increased risk for this devastating disease.” Not only is the ADSP designed to identify genetic risks for late-onset Alzheimer’s disease, he added, but it may also discover protective genes that “could lead to a new era in prevention and treatment.”

     The NIH’s efforts in genome sequencing are part of the National Alzheimer’s Project Act, which became law in 2011 and set five primary goals, including the prevention and effective treatment of Alzheimer’s disease by 2025. Two NIH institutes— the National Human Genome Research Institute (NHGRI) and the National Institute on Aging (NIA) — are collaborating to carry out the ADSP.


     NHGRI Director Eric D. Green, M.D., Ph.D., said in a press release that the “partnership between our two institutes will be immensely helpful in establishing how best to use genome sequencing to elucidate the genomic contributions to complex genetic disorders such as Alzheimer's disease.”

     Stay tuned for continued coverage of advances in genomic sequencing for Alzheimer’s disease. For our previous coverage of neurogenetic research, see our archives: