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What's behind the pathological process of proteins misfolding and aggregating in conditions such as Alzheimer's and multiple system atrophy?


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One study reported finding amyloid-beta pathology in the postmortem brain tissue of patients who developed Creutzfeldt-Jakob disease following childhood treatment with prion-contaminated cadaveric human growth hormone. Another paper found that transgenic animals injected with postmortem brain tissue from people with multiple system atrophy developed aggregates of alpha-synuclein, triggering neurodegeneration and the spread of the disease. Neurology Today editors discuss the findings with David M. Holtzman, MD, FAAN, professor and chair of neurology at Washington University in St Louis. Watch the video: Read the Neurology Today articles: &