Thyroid carcinoma associated with Moyamoya disease has not been reported in the literature. We first described a 46-year-old woman of Moyamoya disease after 10 years of thyroidectomy due to papillary adenocarcinoma of thyroid. During the 10-year medicine history, the patient was treated with levothyroxine (100 µg/d), and thyroid antibody tests demonstrated that elevated thyrotropin receptor antibody sustained for long time. After 10 years, the patient was diagnosed with Moyamoya disease according to digital subtraction angiography findings. The case suggested that thyroid autoimmune stimuli of papillary thyroid carcinoma with thyroid-stimulating hormone receptor antibody may be associated with pathogenic mechanism of Moyamoya disease.
Department of Neurosurgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan Province, China
Supported by grants from the Science and Technology Department of Sichuan Province for Applied Clinical Research (07FG002-029), the Doctoral Fund of Ministry of Education of China (20080441210), and Special Foundation of Sichuan Postdoctor (2009064).
The authors declare no conflict of interest.
Reprints: Chao You, PhD, MD, Department of Neurosurgery, West China Hospital, West China School of Medicine, Sichuan University, No.37, Guoxue Alley, Chengdu 610041, Sichuan Province, China (e-mail: firstname.lastname@example.org).