Case ReportsReversible Leukoencephalopathy Syndrome Owing to Uremia With Anterior Circulation Area Lesions on MRIYerdelen, Deniz MD*; Karatas, Mehmet MD*; Goksel, Basak K. MD*; Yildirim, Tulin MD†Author Information Departments of *Neurology †Radiology, Baskent University Medical School, Adana, Turkey Reprints: Deniz Yerdelen, MD, Department of Neurology, Baskent University Faculty of Medicine, Adana Teaching and Research Center, Dadaloğlu mah, 39 sok, Yüreğir, Adana 01250, Turkey (e-mail: [email protected]). Neurosurgery Quarterly: December 2008 - Volume 18 - Issue 4 - p 294-296 doi: 10.1097/WNQ.0b013e31818d1a6a Buy Metrics Abstract Reversible posterior leukoencephalopathy syndrome (RPLS) describes a syndrome with potentially reversible specific imaging appearance and symptomatology, which is associated with varied causes including hypertension, eclampsia and preeclampsia, immunosuppressive drugs, thrombocytopenic syndromes, and various causes of renal failure. The most common clinical presentations are headaches, mental abnormalities, seizures, and visual disturbances. The typical neuroimaging findings in RPLS include the parietal and occipital lobes. Involvement of additional areas of the brain or main lesions in areas other than the parieto-occipital lobes have been also reported in patients with RPLS. In this report, we describe a 25-year-old man with uremia presented with reversible quadriparesis and lesions in anterior circulation areas of the cerebral hemisphere sparing parieto-occipital regions on magnetic resonance imaging. © 2008 Lippincott Williams & Wilkins, Inc.