Article: PDF OnlyFisher Paul G.; Fry, Terry J.; Wharam, Moody D.Neurosurgery Quarterly: September 1998 - p 216-231 Buy Abstract Summary Primary brain tumors arising during childhood continue to pose an immense challenge for neurosurgeons and other clinicians. These neoplasms are heterogeneous in their histologic composition, potential for metastasis, need for adjuvant therapy, and prognosis for survival. Collectively, children with brain tumors now have a 5-year overall survival rate approximating 60%. Advances in surgical approaches and techniques have contributed greatly to this effort, as reviewed previously here. Equally important to improved survival have been the trials conducted by two national pedi-atric consortiums sponsored by the National Cancer Institute's Clinical Trials Group Program. Clinical studies of brain tumors conducted over the last two decades by these consortiums—the Pediatric Oncology Group (POG) and the Children's Cancer Group (CCG)—are reviewed here, along with basic postsurgical management and standard adjuvant therapies. Past and current POG and CCG studies for medulloblastoma, ependymoma, brain stem glioma, low-grade gliomas, malignant gliomas, germ cell tumors, and infant brain tumors are summarized. Understanding these past and present efforts is of paramount importance to advance management and ultimately survival for childhood brain tumors. © Williams & Wilkins 1998. All Rights Reserved.