Photodynamic Therapy of Cerebral Tumors: PDF OnlyKaye Andrew H.; Hill, John S.Neurosurgery Quarterly: December 1991 - p 233-258 Buy Abstract Summary: Photodynamic therapy is a binary treatment modality involving the selective uptake of a photosensitizer into a tumor followed by irradiation of the tumor with light of the appropriate wavelength to cause activation of the sensitizer. Photodynamic therapy has been extensively investigated in laboratory studies and has been utilised in clinical trials to treat a variety of tumors including cerebral glioma. The clinical trials have usually used PDT as an adjuvant therapy following tumor resection, but studies are being undertaken to use the treatment in combination with stereotactic techniques. The biological basis for photodynamic therapy, and the laboratory studies and clinical trials involving photodynamic therapy to treat cerebral tumors are discussed. Address correspondence and reprint requests to Dr. A. H. Kaye at Department of Neurosurgery, Royal Melbourne Hospital, Melbourne 3050, Victoria, Australia. © Williams & Wilkins 1991. All Rights Reserved.