MOTIVATION, EMOTION, FEEDING, DRINKINGReduced striatal dopamine D2 receptors in people with Internet addictionKim, Sang Heea; Baik, Sang-Hyuna; Park, Chang Soob; Kim, Su Jinb; Choi, Sung Wonc; Kim, Sang EunbAuthor Information aDepartment of Brain and Cognitive Engineering, Korea University bDepartment of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea cDepartment of Industrial and Advertising Psychology, Daejeon University, Daejeon, Korea Correspondence to Sang Eun Kim, MD, PhD, Department of Nuclear Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam 463-707, Korea Tel: +82 31 787 7671; fax: +82 31 787 4018; e-mail: [email protected] and Correspondence to Sang Hee Kim, PhD, Department of Brain and Cognitive Engineering, Science Library 309D, Korea University, Anam-dong 5ga, Seongbuk-gu, Seoul 136-713, Korea Tel: +82 2 3290 5923; fax: +82 2 3290 3586; e-mail: [email protected] Received February 21, 2011 Accepted March 17, 2011 NeuroReport: June 11, 2011 - Volume 22 - Issue 8 - p 407-411 doi: 10.1097/WNR.0b013e328346e16e Buy Metrics Abstract An increasing amount of research has suggested that Internet addiction is associated with abnormalities in the dopaminergic brain system. We hypothesized that Internet addiction would be associated with reduced levels of dopaminergic receptor availability in the striatum compared with controls. To test this hypothesis, a radiolabeled ligand [11C]raclopride and positron emission tomography was used to assess dopamine D2 receptor binding potential in men with and without Internet addiction. Consistent with our prediction, individuals with Internet addiction showed reduced levels of dopamine D2 receptor availability in subdivisions of the striatum including the bilateral dorsal caudate and right putamen. This finding contributes to the understanding of neurobiological mechanism of Internet addiction. © 2011 Lippincott Williams & Wilkins, Inc.