COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYA supramodal network for response inhibitionWalther, Stephana b; Goya-Maldonado, Robertoa c; Stippich, Christophb d; Weisbrod, Matthiasa e; Kaiser, Stefana fAuthor Information aSection of Experimental Psychopathology, Department of Psychiatry bDepartment of Neuroradiology, University of Heidelberg cMax Planck Institute of Psychiatry, Munich dDepartment of Neuroradiology, University of Basel eDepartment of Psychiatry, SRH Hospital Karlsbad-Langensteinbach fPsychiatric University Hospital, Zurich, Germany Correspondence to Stephan Walther, Section of Experimental Psychopathology, Department of Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Voss-Strasse 4, EEG-Laboratory, Germany Tel: +49 6221 565412; fax: +49 6221 568094; e-mail: [email protected] Received 7 September 2009 accepted 15 November 2009 NeuroReport: February 17, 2010 - Volume 21 - Issue 3 - p 191-195 doi: 10.1097/WNR.0b013e328335640f Buy Metrics Abstract Response inhibition is the capacity to suppress inappropriate actions and is considered to be a fundamental executive function. This study investigated whether the neural correlates of response inhibition are organized along supramodal or modality-specific principles. For this purpose, we used event-related functional magnetic resonance imaging in a go-nogo task with auditory and visual stimuli. Common activation relating to response inhibition across modalities was observed in a frontoparietal network including the ventrolateral prefrontal cortex. In contrast, there was no modality-specific activation related to response inhibition in the prefrontal cortex. These findings suggest that the neural correlates of response inhibition have a supramodal organization, which is consistent with its role as a core executive function. © 2010 Lippincott Williams & Wilkins, Inc.