BRAIN IMAGINGIs migraine a lateralization defect?Kaaro, Jania; Partonen, Timob; Naik, Paulamic; Hadjikhani, Nouchinec d eAuthor Information aAV-Torppa Oy, Lohja bNational Public Health Institute, Helsinki, Finland cAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown dDivision of Health Sciences and Technology, Harvard-MIT, Cambridge, Massachusetts, USA eBrain Mind Institute, EPFL, Lausanne, Switzerland Correspondence to Nouchine Hadjikhani, MD, Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Charlestown, MA 02129, USA Tel: +1 617 724 5625; fax: +1 530 309 4973; e-mail: firstname.lastname@example.org Received 20 May 2008 accepted 11 June 2008 NeuroReport: August 27th, 2008 - Volume 19 - Issue 13 - p 1351-1353 doi: 10.1097/WNR.0b013e32830c4698 Buy SDC Metrics Abstract Migraine often co-occurs with patent foramen ovale (PFO), and some people have suggested surgical closure as an efficient treatment for migraine. Prospective studies, however, do not report radical effect of PFO surgery on migraine. Here, we examined the hypothesis that PFO and migraine may cooccur as two independent manifestations of lateralization defect during embryonic development. We measured the absolute displacement of a midline structure, the pineal gland, on brain scans of 39 migraineurs and 26 controls. We found a significant asymmetry of the pineal gland in migraineurs compared with controls. Our data suggest that migraine's circadian component and its association with PFO may be linked to a lateralization defect during embryogenesis, which could be a result from abnormal serotonin regulation. © 2008 Lippincott Williams & Wilkins, Inc.