BRAIN IMAGINGMusic in minor activates limbic structures: a relationship with dissonance?Green, Anders C.a c d; Bærentsen, Klaus B.a c; Stødkilde-Jørgensen, Hansc; Wallentin, Mikkeld; Roepstorff, Andreasb d; Vuust, Peterd e Author Information aDepartments of Psychology bAnthropology, University of Aarhus cMR Research Centre dCenter of Functionally Integrative Neuroscience, Aarhus University Hospital eRoyal Academy of Music, Aarhus, Denmark Correspondence to Anders C. Green, Department of Psychology, University of Aarhus, Jens Chr. Skous Vej 4, DK-8000 Aarhus C, Denmark Tel: +45 89424900; fax: +45 89424901; e-mail: [email protected] Received 4 February 2008; accepted 13 February 2008 NeuroReport: May 7, 2008 - Volume 19 - Issue 7 - p 711-715 doi: 10.1097/WNR.0b013e3282fd0dd8 Buy Metrics Abstract Using functional magnetic resonance imaging, we contrasted major and minor mode melodies controlled for liking to study the neural basis of musical mode perception. To examine the influence of the larger dissonance in minor melodies on neural activation differences, we further introduced a strongly dissonant stimulus, in the form of a chromatic scale. Minor mode melodies were evaluated as sadder than major melodies, and in comparison they caused increased activity in limbic structures, namely left parahippocampal gyrus, bilateral ventral anterior cingulate, and in left medial prefrontal cortex. Dissonance explained some, but not all, of the heightened activity in the limbic structures when listening to minor mode music. © 2008 Lippincott Williams & Wilkins, Inc.