BEHAVIOURInactivation of the lateral septum blocks fox odor-induced fear behaviorEndres, Thomasa; Fendt, Markusa b Author Information aAnimal Physiology, Zoological Institute, Faculty of Biology, University of Tübingen, Germany bNovartis Institutes for BioMedical Research, Neuroscience DA, Novartis Campus, Basel, Switzerland Correspondence to Thomas Endres, Tierphysiologie, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany Tel: +49 0 071 2976134; fax: +49 07071 292618; e-mail: [email protected] Received 22 January 2008; accepted 3 February 2008 NeuroReport 19(6):p 667-670, April 16, 2008. | DOI: 10.1097/WNR.0b013e3282fb78d9 Buy Metrics Abstract A number of lesion studies have shown that the lateral septum plays an important role in the modulation of innate fear. Furthermore, an increased c-fos expression in the lateral septum was demonstrated after exposure to natural predator odors and 2,3,5,-trimethyl-3-thiazoline (TMT), a component of fox odor. This study investigates, on a behavioral level, whether the lateral septum plays a role in TMT-induced fear. Temporary inactivation of the lateral septum by local muscimol injections clearly blocked TMT-induced fear behavior but had no effect on behavior in a controlled condition. This indicates that the lateral septum is important for the processing of TMT-induced fear and suggests that the lateral septum is also involved in fear behavior induced by natural predator odors. © 2008 Lippincott Williams & Wilkins, Inc.