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Glucose reverses fasting-induced activation in the arcuate nucleus of mice

Becskei, Csilla; Lutz, Thomas A.; Riediger, Thomas

doi: 10.1097/WNR.0b013e3282f380a2
NEUROPHYSIOLOGY, BASIC AND CLINICAL
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The hypothalamic arcuate nucleus is an important target for metabolic and hormonal signals controlling food intake. As demonstrated by c-Fos studies, arcuate neurons are activated in food-deprived mice, whereas refeeding reverses the fasting-induced activation. To evaluate whether an increase in blood glucose has an inhibitory effect on these neurons, we analyzed the c-Fos response to an intraperitoneal glucose injection in fasted mice. This treatment increased blood glucose levels twofold and reduced 2-h food intake. Similar to refeeding, it also reversed the fasting-induced activation in the arcuate nucleus. Therefore, an increase in blood glucose might be an important feeding-related signal acting via the arcuate nucleus to oppose orexigenic stimuli.

Institute of Veterinary Physiology and Zurich Centre of Integrative Human Physiology, University of Zurich, Zurich, Switzerland

Correspondence to Csilla Becskei, Institute of Veterinary Physiology, University of Zurich, Winterthurerstrasse 260, Zurich 8057, Switzerland

Tel: +41 44 635 8812; fax: +41 44 635 8932; e-mail: csillab@vetphys.uzh.ch

Received 8 October 2007; accepted 18 October 2007

© 2008 Lippincott Williams & Wilkins, Inc.