BRAIN IMAGINGShape deformation of the insula in alcoholics: reduction of left–right asymmetryJung, Young Chula b; Jang, Dong-Pyoc; Namkoong, Keea b; Ku, Jeonghund; Kim, Jae-Jina b; Park, Sangjine; Cho, Zang-Heec; Kim, Young-Boc; Lee, Eune Author Information aDepartment of Psychiatry, Yonsei University College of Medicine, Seoul bInstitute of Behavioral Science in Medicine, Yonsei University College of Medicine, Gyeonggi-do cNeuroscience Research Institute, Gachon University of Medicine and Science, Incheon dDepartment of Biomedical Engineering, Hanyang University, Seoul eDepartment of Psychiatry, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do, Korea Correspondence to Eun Lee, MD, Department of Psychiatry, National Health Insurance Corporation Ilsan Hospital, 1232, Baekseok-dong, Ilsandong-gu, Goyang, Gyeonggi-do, 410-719, South Korea Tel: +82 31 900 0480; fax: +82 31 900 0481; e-mail: [email protected] Received 13 August 2007; accepted 27 August 2007 NeuroReport 18(17):p 1787-1791, November 19, 2007. | DOI: 10.1097/WNR.0b013e3282f193b4 Buy Metrics Abstract We have investigated shape deformation of the insula to get a viewpoint of how chronic alcohol consumption affects the perisylvian region and compared the deformity pattern between the left and right hemisphere. A landmark-based structural and surface shape analysis of the insula was performed in 20 patients with alcohol dependence and 20 controls matched for age. The shape analysis revealed that the left and right insula follow distinct shape deformation patterns, which resulted in the reduction of left–right asymmetry. The shape deformity was most prominent in the central part of both insula. Our findings indicate that the right and left hemisphere are both affected but shows distinct patterns of deformation in alcohol dependence. © 2007 Lippincott Williams & Wilkins, Inc.