CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYRelationship between P50 suppression and the cortical silent periodMöller, Bertrama c; Light, Gregory A.d; Fitzgerald, Paul B.f; Snyder, Joel S.e; Chen, Robertb; Daskalakis, Zafiris J.a Author Information aSchizophrenia Program, Centre for Addiction and Mental Health bDivision of Neurology and Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada cDepartment of Psychiatry, Ernst Moritz Arndt University of Greifswald, Mecklenburg-Vorpommern, Germany dDepartment of Psychiatry, University of California, San Diego, California eDepartment of Psychiatry, VA Boston Healthcare System/Harvard Medical School, Boston, Massachusetts, USA fPsychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Victoria, Australia Correspondence to Zafiris Jeff Daskalakis, MD, PhD, FRCP(C), Staff Psychiatrist, Schizophrenia Program, Associate Professor of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, 7th Floor, M5T 1R8, Toronto, Ontario, Canada Tel: +416 535 8501, ext: 4319; fax: +416 979 6936; e-mail: [email protected] Received 8 May 2007; accepted 15 June 2007 NeuroReport 18(14):p 1503-1506, September 17, 2007. | DOI: 10.1097/WNR.0b013e3282ef6a29 Buy Metrics Abstract Deficient inhibitory neurotransmission has been demonstrated in schizophrenia through electroencephalography (e.g. P50 suppression) and transcranial magnetic stimulation (e.g. short-interval cortical inhibition and the cortical silent period). It is not known whether these inhibitory paradigms are related despite evidence suggesting that both are coordinated through γ-aminobutyric acid inhibitory neurotransmission. We explored the relationship between P50 suppression, short-interval cortical inhibition and the cortical silent period in 21 healthy participants using previously published methods. P50 suppression was significantly correlated with cortical silent period (r=−0.49, P=0.02) but not with short-interval cortical inhibition. As both P50 suppression and the cortical silent period have been linked to γ-aminobutyric acidB receptor-mediated inhibitory neurotransmission, these data highlight the importance of this receptor subtype in the pathophysiology of schizophrenia. © 2007 Lippincott Williams & Wilkins, Inc.