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Theta resynchronization during reconsolidation of remote contextual fear memory

Narayanan, Rajeevan T.; Seidenbecher, Thomas; Sangha, Susan; Stork, Oliver; Pape, Hans-Christian

doi: 10.1097/WNR.0b013e3282004992
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We have recently demonstrated high theta-phase synchronization between the lateral amygdala and CA1 area of the hippocampus during retrieval of long-term (1 day) fear memory, and not during short-term (2 h) or remote memory retrieval (30 days). These results indicated that the amygdalo-hippocampal interaction reflects a dynamic change of ensemble activities related to various stages of fear memory storage. In this study, we investigated theta activity during the reconsolidation of a remote contextual fear memory by re-exposing animals to the shock context 30 days after training. Consistent with our previous results, high theta synchronization was no longer apparent during re-exposure to the shock context, but was significantly higher 1 day after context re-exposure. These data indicate that the reconsolidation of remote contextual fear memory includes changes in ensemble activities between the lateral amygdala and CA1.

aInstitute of Physiology I, Westfälische Wilhelms-University Münster

bInstitute of Physiology, Otto-von-Guericke University Magdeburg, Germany

Correspondence to Hans-Christian Pape, Institut of Physiology I, Westfälische Wilhelms-University Münster, Robert-Koch-Str. 27a, 48149 Münster, Germany

Tel: +49 0 251 835 5542; fax: +49 0 251 835 5551; e-mail: papechris@ukmuenster.de

Received 26 February 2007; accepted 29 March 2007

© 2007 Wolters Kluwer Health | Lippincott Williams & Wilkins