NEUROENDOCRINOLOGYCardiovascular response to renin substrate microinjection into the central nucleus of the amygdala of ratsHeshmatian, Behnama b; Parviz, Mohsena; Karimian, Sayed Mortezaa; Keshavarz, Mansoora; Sohanaki, HamidaAuthor Information aDepartment of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran bDepartment of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Correspondence to Mohsen Parviz, Department of Physiology, School of Medicine, Tehran university of Medical Sciences, Tehran, Iran Tel/fax: +982166419484; e-mail: [email protected] Received 5 December 2006 accepted 20 December 2006 NeuroReport: May 7th, 2007 - Volume 18 - Issue 7 - p 675-678 doi: 10.1097/WNR.0b013e3280ba49d8 Buy Metrics Abstract Central nucleus of the amygdala is involved in cardiovascular regulation. Although most components of the renin–angiotensin system have been found to be distributed in amygdala, renin expression in brain has remained controversial. This work was undertaken to elucidate the extent of renin presence in this nucleus. A cannula was implanted bilaterally into the central nucleus of the amygdala. Mean arterial pressure and heart rate were directly measured via indwelling femoral artery cannula post bilateral intra central nucleus of the amygdala microinjection of renin substrate. Renin substrate microinjection dose-dependently increased mean arterial pressure and heart rate, whereas captopril, saralasin and losartan pretreatment inhibited these effects. The results suggest the presence of local renin or similar proteases in this nucleus. © 2007 Lippincott Williams & Wilkins, Inc.